60M with GI Disorders
G-Tech Clinical Trial
Gluten and Celiac Disease
Gluten and your GUT
Smooth muscle cells are interconnected by ‘gap junctions’ - specialized communication ports ￼between the cells which are permeable to ions and therefore transmit electrical current between smooth muscle cells, allowing sheets/bundles of cells to quickly and efficiently contract as a unit. The resting membrane potential as a function of ionic concentrations in the intracellular and extracellular fluids of the smooth muscle cell is maintained between -60 and -70 mV. (Figure 4) Slow waves are the result of slow changes in the resting membrane potential due to ionic fluxes in the ranges of 5 to 15 mv which spread from cell to cell through the gap junctions. Slow waves do not result in muscle contractions. When the slow wave potential crosses the threshold potential action potentials, which are quick bursts of activity, appear on the crest of the slow waves. These spike bursts result in muscle contractions which narrow the lumen and thus cause movement of the luminal content.
Each day about a liter of material is introduced into your colon through the ileum, largely water, salt and fiber that has not been absorbed in the small intestines. The seemingly rapid transit through the small intestine is slowed down to a sluggish crawl as we hit the colon with it taking up to 24 hours for the material to move from the cecum to the rectum. When the material gets to 100 grams in the rectum it triggers a bowel movement.
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